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iCANX Talks Special Issue

第三屆吳望一生物力學杰出貢獻獎

2021 Wu Wang-Yi Distinguished Achievement Lecture on Biomechanics

2021年11月19日上午8：30（北京時間），大家期待已久的 iCANX Talks迎來一次特別活動：第三屆“吳望一生物力學杰出貢獻獎”的頒獎典禮和講座。本次的獲獎人是美國科學家Larry V. McIntire教授，他為大家做題為《Mechanobiology : from Cells to Molecules in Vascular Biology》（力學生物學:從細胞到分子的血管生物學）的學術報告。屆時，吳望一教授的女兒吳江老師與曾經在北大生物力學吳望一教授課題組學習和工作過的杰出校友，以及北大生物醫(yī)學工程系的師生們將共聚一堂，以學術紀念吳望一先生，敬請期待！

“2021 Wu Wang-Yi Distinguished Achievement Lecture on Biomechanics ” will be ceremoniously held on iCANX Talks at 8:30AM on November 19 2021 (Beijing time). This year, the recipient is Professor Larry V. McIntire, a scientist from Georgia Institute of Technology, USA, he will deliver a talk in title“ Mechanobiology : from Cells to Molecules in Vascular Biology” . Meanwhile, Professor Wangyi Wu's daughter Jiang Wu with Distinguished alumni from Professor Wangyi Wu's research group and colleagues of Biomedical Engineering of Peking University will gather online. Stay tuned!

吳望一生物力學杰出貢獻獎

北京大學生物力學課題組成立于上個世紀80年代初。在已故吳望一教授、溫功碧教授和嚴宗毅教授的領導下，北京大學組成為最先在中國開展了生物力學研究和人才培養(yǎng)工作的單位之一。這個生物力學課題組不僅在研究上取得了豐碩的成果，而且培養(yǎng)了一大批高素質的本科生、研究生和博士后。他們中的很多人都已成為中國及世界上生物力學和生物醫(yī)學工程領域的知名學者和領導者。2011年，北大工學院為表彰吳望一教授對生物力學的貢獻，設立了“吳望一生物力學杰出貢獻獎”。這個獎項由北大工學院及原北大生物力學課題組的學生和吳望一教授家屬捐款建立的“吳望一教授生物力學杰出貢獻基金”資助。

The Biomechanics Research Group of Peking University was founded in the early 1980s. Under the leadership of the late Prof. Wu, Wangyi, Prof. Wen, Gongbi and Prof. Yan, Zongyi, Peking University was one of the first institutions to carry out biomechanics research and talent training in China. This biomechanics research group has not only achieved outstanding results in research, but also cultivated a large number of high-quality undergraduates, postgraduates and postdocs. Many of them have become renowned scholars and leaders in the field of biomechanics and biomedical engineering in China and around the world. In 2011, The College of Engineering at Peking University established the "Wu Wang-Yi Award for Distinguished Achievements on Biomechanics" in recognition of his contributions to biomechanics. This award is funded by the " Wu Wang-Yi Distinguished Achievement Lecture on Biomechanics Foundation ", which was established by the students of College of Engineering of Peking University, former PKU Biomechanics research group and Professor Wu, Wangyi's family.

這個獎項目前已頒發(fā)給了兩位世界著名生物醫(yī)學工程科學家，第一位是美國University of California, San Diego大學的錢煦 (Shu Chien) 教授 (2011年), 另一位是美國City College of New York的Sheldon Weinbaum教授 (2015年)。今年，這個獎項將頒給美國Georgia Institute of Technology大學的Larry McIntire教授。這三位獲獎教授除了都是生物醫(yī)學領域的世界頂級學者以外，還有一個共同點就是他們都為北大和中國的生物醫(yī)學工程發(fā)展做出了重大貢獻。

The prize has now been awarded to two world-renowned Biomedical Engineering scientists, The first is Prof. Shu Chien of University of California, San Diego (2011), and the second is Prof. Sheldon Weinbaum of City College of New York (2015). This year, the prize will go to Professor Larry V. McIntire of the Georgia Institute of Technology in the United States. The three professors are recognized for their significant contributions to the development of Biomedical Engineering at Peking University and in China.

每次在頒發(fā)“吳望一生物力學杰出貢獻獎”的同時，還會舉辦“北京大學生物力學及計算醫(yī)學高級研討會”。今年由于COVID-19疫情還未結束，我們將以網上系列講座的形式分享和討論這些領域里的最新研究成果。獲獎人Larry McIntire教授的報告是今年研討會的第一講。

At the same time of awarding "Wu Wang-Yi Distinguished Achievement Lecture on Biomechanics”, "Peking University Advanced Seminar on Biomechanics and Computational Medicine" will also be held. This year, as the COVID-19 pandemic continues, we will share and discuss the latest research in these areas via online lecture series. The first speaker will be Professor Larry McIntire, recipient of this year's Wu Wang-Yi Award for Distinguished Achievements on Biomechanics.

吳望一先生簡介

吳望一，我國知名流體力學、生物力學專家，中國生物力學領域的創(chuàng)始人之一。1933年6月8日出生于浙江省寧波市。1953年北京大學數學系畢業(yè)后留校任教。1985任北京大學力學系教授、博導。于1982, 1990年先后在美國哥倫比亞大學和紐約市立大學作訪問學者。歷任北大力學系流體力學教研室和生物力學研究室主任、生物力學專業(yè)委員會副主任、力學學會理事、力學學會教育工作委員會副主任、應用數學和力學常務編委、大百科全書力學卷流體力學分支副主編等職。吳教授長期從事生物力學和計算流體力學的研究，是我國在生物力學領域的創(chuàng)始人之一。發(fā)表論文近百篇。他編著的《流體力學》（上、下冊），1988年獲國家教委首屆高校優(yōu)秀教材二等獎，并被臺灣大學選為教材，由臺北歐亞書局以中文繁體字出版。在國內1982出版后，被眾多高校選為教材或參考書，至今已印刷十次。他培養(yǎng)過了研究生、博士后40多名。為了表彰他對我國生物力學的貢獻，北京大學工學院于2011年設立了“吳望一生物力學杰出貢獻獎”。

2021北京大學生物力學及計算醫(yī)學高級研討會

Peking University Advanced Seminar on Biomechanics and Computational Medicine

Mechanobiology : from Cells to Molecules in Vascular Biology

力學生物學:從細胞到分子的血管生物學

Larry V. McIntire

Wallace H Coulter Chair Emeritus, Georgia Institute of Technology

Abstract

Understanding the detailed coupling of local mechanics and cell biology in the cardiovascular system remains an exciting challenge. This interplay is important in various pathologies including atherosclerosis, arterial thrombosis, and infectious diseases. This seminar will discuss examples of flow effects on endothelial cell metabolism and gene expression profiles and of flow regulation of the molecular mechanisms of platelet/endothelial cell interactions via the platelet GP1b complex and EC von Willebrand factor. We conclude with a discussion of actin depolymerization under force at the molecular level and its mediation by catch-slip bonds.

了解心血管系統(tǒng)中局部力學和細胞生物學的詳細耦合仍然是一個令人興奮的挑戰(zhàn)。這種相互作用在各種病理中都很重要，包括動脈粥樣硬化、動脈血栓形成和感染性疾病。本次報告將討論流動對內皮細胞代謝和基因表達譜的影響，以及通過血小板GP1b復合物和EC von Willebrand因子來調節(jié)血小板/內皮細胞相互作用的分子機制。最后，我們討論了肌動蛋白在分子水平上的解聚作用及其通過俘獲滑移鍵的中介作用。

Biography

Dr. Larry V. McIntire joined the Georgia Institute of Technology and the Emory University School of Medicine in 2003 as the Wallace H. Coulter Professor and Chair of the Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.During his tenure, he jointly promoted the PKU/GT/Emory Joint PhD Program with the Department of Biomedical Engineering of Peking University. This is the first joint doctor program approved in China by the Academic Degree Office of the State Council.This mode of cultivating joint doctoral students has become an important symbol of graduate student education of the College of Future Technology of Peking Universty. Moreover, it also sets up a model for joint graduate student education between China and the United States. It generates significant influence in Chinese and American universities.

Dr.McIntire received degrees from Cornell University in 1966 and his PhD from PrincetonUniversity in 1970 -- all in chemical engineering. He joined Rice University in January 1970as an Assistant Professor. He is the author of more than 400 publications and papers in the areas of bioengineering applications in vascular biology, thrombosis, atherosclerosis, and inflammation.

Dr.McIntire is past President of the American Institute of Medical and Biological Engineering and is past Presidentof the Biomedical Engineering Society. In 1998, he was elected a Fellow of the American Association for theAdvancement of Science. In 2001, Dr. McIntire was elected to the National Academy of Engineering and wasappointed Editor-in-Chief of the Annals of Biomedical Engineering, effective January 2002 – December, 2009.

Larry V. McIntire博士于2003年加入佐治亞理工學院和埃默里大學醫(yī)學院擔任Wallace H. Coulter教授，以及擔任佐治亞理工學院和埃默里大學華萊士.科特生物醫(yī)學工程系的系主任。在任期間，他與北京大學生物醫(yī)學工程系共同推進了北京大學/佐治亞理工/艾默里大學聯(lián)合博士培養(yǎng)項目，這是中國首個由國務院學位辦審批的聯(lián)合博士培養(yǎng)項目，已成為北大未來技術學院博士生教育和中美研究生聯(lián)合培養(yǎng)的重要標志，在中美高校產生了重要的影響。

他于1966年畢業(yè)于康奈爾大學，1970年獲得普林斯頓大學博士學位。他于1970年1月加入萊斯大學，擔任助理教授。他在血管生物學、血栓形成、動脈粥樣硬化和炎癥等生物工程應用領域發(fā)表了400多篇論文。

他是The American Institute of Medical and Biological Engineering的前主席，以及The Biomedical Engineering Society的前主席。1998年被選為美國科學促進會的會員。2001年入選美國工程院院士，并被任命為Annals of Biomedical Engineering的主編(2002年1月至2009年12月)。

Keywords

Wangyi Wu吳望一

Biomechanics 生物力學

Distinguished Achievement 杰出貢獻獎

Peking University 北京大學

iCANX

同時，本次講座也邀請了來自加州大學圣地亞哥分校的Peter Yingxiao Wang教授帶來精彩的主持。來自佐治亞理工學院的Cheng Zhu教授和杜克大學的Fan Yuan教授擔任嘉賓,來自北京大學工學院的楊越教授和來自北京大學未來技術學院的肖瑞平教授、席建忠教授也將到會分享。精彩不斷，敬請期待！iCANX將繼續(xù)努力，為科學交流服務，提供一個全球學術交流的頂級平臺，敬請大家期待！

At the same time, this lecture also invited Professor Peter Yingxiao Wang from University of California, San Diego to bring a wonderful host. Professor Cheng Zhu from the Georgia Institute of Technology and professor Fan Yuan from Duke University, Professor Yue Yang from College of Engineering, Professor Ruiping Xiao, Professor Jianzhong Xi from College of Future Technology as guests. iCANX will continue to work hard to serve scientific exchanges and provide a top platform for global academic exchanges. Please look forward to it!

每一期iCANX Talks直播結束后，都深受參會者好評，不僅為感興趣的參會者和讀者深度理解相關技術提供了幫助，也為研究生深入開展科研提供了一個很好的平臺。更多精彩，盡在iCANX Talks ！

歡迎大家掃碼觀看直播！

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